Publications

1.   Dick DM, Nasim A, Edwards AC, Salvatore J, Cho SB, Adkins A, Meyers J, Yan J, Cooke M, Clifford J, Goyal N, Halberstadt L, Ailstock K, Neale Z, Oplaesky J, Hancock L, Donovan KK, Sun C, Riley B, Kendler KS. Spit for Science: Launching a longitudinal study of genetic and environmental influences on substance use and emotional health at a large US university. Frontiers in Genetics (Behavioral and Psychiatric), 2014 Mar 6;5:47. doi: 10.3389/fgene.2014.00047. PMID: 24639683. PMCID: PMC3944794

Abstract: Finding genes involved in complex behavioral outcomes, and understanding the pathways by which they confer risk, is a challenging task, necessitating large samples that are phenotypically well characterized across time. We describe an effort to create a university-wide research project aimed at understanding how genes and environments impact alcohol use and related substance use and mental health outcomes across time in college students. Nearly 70% of the incoming freshman class (N = 2715) completed on-line surveys, with 80% of the students from the fall completing spring follow-ups. 98% of eligible participants also gave DNA. The participants closely approximated the university population in terms of gender and racial/ethnic composition. Here we provide initial results on alcohol use outcomes from the first wave of the sample, as well as associated predictor variables. We discuss the potential for this kind of research to advance our understanding of genetic and environment influences on substance use and mental health outcomes.

2.   Salvatore JE, Kendler KS, Dick DM. Romantic relationship status and alcohol use and problems across the first year of college. Journal of Studies on Alcohol and Drugs. 2014 Jul;75(4)580-9. PMID: 24988257. PMCID: PMC4108599

Abstract: Objective: We examined the associations between romantic relationship status and alcohol use and problems in a large sample of first-year college students. Method: Participants (n = 2,056) came from a longitudinal study of college students who answered questions about relationship status (single, in an exclusive relationship, or dating several people), alcohol use, and alcohol problems at two time points across their first year. Results: After we controlled for a number of covariates (parental alcohol problems, high school conduct problems, peer deviance, and extraversion), we found that dating several people was associated with higher alcohol use and problems, compared with being single or being in an exclusive relationship, at the follow-up assessment only, with modest effect sizes. Being in an exclusive relationship was not associated with lower alcohol use or problems compared with being single. Relationship dissolution was associated with a modest longitudinal increase in alcohol problems. Conclusions: It is important to consider alternative relationship statuses (e.g., dating several people) for understanding the association of romantic status with alcohol use and problems in college-aged samples. Involvement in an exclusive romantic relationship (vs. being single) in this age group is not associated with the behavioral health benefits documented in older-adult samples. College students dating several people may be at risk for high levels of alcohol use or problems and may benefit from targeted interventions. Those who have recently experienced a breakup also may be at risk for increases in alcohol problems, although the clinical relevance of this finding should be tempered by the small observed effect size.

3.   Kendler KS, Myers J, Dick DM. The stability and predictors of peer group deviance in university students. Social Psychiatry and Psychiatric Epidemiology. 2015 Sep;50(9):1463-70. doi: 10.1007/s00127-015-1031-4. Epub 2015 Feb 22. PMID: 25702166. PMCID: PMC454657

Abstract: Peer group deviance (PGD) is strongly associated with current and future externalizing behaviors. Debate remains about the degree to which this association arises from social selection. The first year of university constitutes a social experiment in which most individuals leave their home environment and recreate for themselves a new peer group. Methods:  PGD was measured in newly arrived university students and then 6 and 18 months later. Other personality and family traits were also assessed Results: PGD reported for high school friends at the start of university and university friends 6 months later were substantially correlated (+0.60). This correlation was only slightly diminished if restricted to students whose home was greater than 50 miles from the university. PGD was strongly predicted across three cohorts by male sex (+), extraversion (+), conscientiousness (-), a family history of alcohol use disorders (+) and depression (+), and religiosity (-).These predictors of PGD had a relatively stable impact over 18 months and, aside from sex, differed only modestly in males and females. Conclusions: As individuals change social groups from high school to university, the level of PGD remains relatively stable, suggesting that individuals play a strong role in selecting peer groups with consistent characteristics. PGD is also predicted cross-sectionally and longitudinally by personality, family background and religiosity. Our results suggest that the association between personal and peer deviance is due at least in part to the effects of social selection.

4.   Dick DM, Hancock LC. Integrating basic research with prevention/intervention to reduce risky substance use among college students. Frontiers in Psychology. 2015 May 7;6544. doi: 10.3389fpsyg.2015.00544. eCollection 2015. PMID: 25999878. PMCID: PMC4423347

Abstract: Too often basic research on etiological processes that contribute to substance use outcomes is disconnected from efforts to develop prevention and intervention programming. Substance use on college campuses is an area of concern where translational efforts that bring together basic scientists and prevention/intervention practitioners have potential for high impact. We describe an effort at a large, public, urban university in the United States to bring together researchers across the campus with expertise in college behavioral health with university administration and health/wellness practitioners to address college student substance use and mental health. The project “Spit for Science” examines how genetic and environmental influences contribute to behavioral health outcomes across the college years. We argue that findings coming out of basic research can be used to develop more tailored prevention and intervention programming that incorporates both biologically and psychosocially influenced risk factors. Examples of personalized programming suggest this may be a fruitful way to advance the field and reduce risky substance use.

5.   Kendler KS, Edwards A, Myers J, Cho SB, Adkins A, Dick D. The predictive power of family history measures of alcohol and drug problems and internalizing disorders in a college population. American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 2015 July;168(5):337-46. doi: 10.1002/ajmg.b.32320. Epub 2015 May 6. PMID: 25946510. PMCID: PMC4466079 [Available on 2016-7-1]

Abstract: A family history (FH) of psychiatric and substance use problems is a potent risk factor for common internalizing and externalizing disorders. In a large web-based assessment of mental health in college students, we developed a brief set of screening questions for a FH of alcohol problems (AP), drug problems (DP) and depression-anxiety in four classes of relatives (father, mother, aunts/uncles/grandparents, and siblings) as reported by the student. Positive reports of a history of AP, DP, and depression-anxiety were substantially correlated within relatives. These FH measures predicted in the student, in an expected pattern, dimensions of personality and impulsivity, alcohol consumption and problems, smoking and nicotine dependence, use of illicit drugs, and symptoms of depression and anxiety. Using the mean score from the four classes of relatives was more predictive than using a familial/sporadic dichotomy. Interactions were seen between the FH of AP, DP, and depression-anxiety and peer deviance in predicting symptoms of alcohol and tobacco dependence. As the students aged, the FH of AP became a stronger predictor of alcohol problems. While we cannot directly assess the validity of these FH reports, the pattern of findings suggest that our brief screening items were able to assess, with some accuracy, the FH of substance misuse and internalizing psychiatric disorders in relatives. If correct, these measures can play an important role in the creation of developmental etiologic models for substance and internalizing psychiatric disorders which constitute one of the central goals of the overall project.

6.  Conley A, Overstreet CM, Hawn SE, Kendler KS, Dick DM, Amstadter AB. Prevalence and predictors of sexual assault among a college sample. American Journal of Public Health. 2016 Sep 14:1-9. [Epub ahead of print]. doi: 10.1080/07448481.2016.1235578  PMID: 27628533

Abstract: This study examined the prevalence and correlates of precollege, college-onset, and repeat sexual assault (SA) within a representative student sample. PARTICIPANTS:  A representative sample of 7,603 students. METHODS: Incoming first-year students completed a survey about their exposure to broad SA prior to college, prior trauma, personality, relationships, and mental health. Broad SA was then reassessed each spring semester while enrolled. RESULTS: Nearly 20% of the sample reported experiencing broad SA, with women endorsing significantly higher rates compared with males. Prior victimization before coming to college was related to a greater risk of victimization in college, and there was no statistically significant difference between males and females who reported revictimization. Correlates of college-onset broad SA were found and are discussed. CONCLUSIONS:  Given the need for SA intervention and prevention on college campuses, identification of factors potentially contributing to exposure within this population is essential.

7.   Savage JE, Neale Z, Cho SB, Hancock L, Kalmijn JA, Smith TL, Schuckit MA, Kidd Donovan K, Dick DM. Level of response to alcohol as a factor for targeted prevention in college students. Alcoholism: Clinical and Experimental Research. 2015

Abstract: Heavy alcohol consumption and alcohol problems among college students are widespread and associated with negative outcomes for individuals and communities. Although current methods for prevention and intervention programming have some demonstrated efficacy, heavy drinking remains a problem. A previous pilot study and a recent large-scale evaluation (Schuckit et al., , ) found that a tailored prevention program based on a risk factor for heavy drinking, low level of response (low LR) to alcohol, was more effective at reducing heavy drinking than a state-of-the-art (SOTA) standard prevention program for individuals with the low LR risk factor. Methods:  This study enrolled 231 first-semester college freshmen with either high or low LR into the same level of response-based (LRB) or SOTA online prevention programs as in the previous reports (consisting of 4 weeks of video modules), as well as a group of matched controls not receiving alcohol prevention, and compared changes in alcohol use between these groups across a 6-month period. Results:  Individuals in alcohol prevention programs had a greater reduction in maximum drinks per occasion and alcohol use disorder symptoms than controls. There was limited evidence for interactions between LR and prevention group in predicting change in alcohol use behaviors; only among participants with strict adherence to the program was there an interaction between LR and program in predicting maximum drinks per occasion. However, overall, low LR individuals showed greater decreases in drinking behaviors, especially risky behaviors (e.g., maximum drinks, frequency of heavy drinking) than high LR individuals. Conclusions:  These results indicate that prevention programs, including brief and relatively inexpensive web-based programs, may be effective for persons at highest risk for heavier drinking, such as those with a low LR. Tailored programs may provide incremental benefits under some conditions. Long-term follow-ups and further investigations of tailored prevention programs based on other risk factors are needed.

8.   Berenz EC, Cho SB, Overstreet C, Kendler K, Amstadter AB, Dick DM. Longitudinal investigation of interpersonal trauma exposure and alcohol use trajectories. Addictive Behaviors. 2016 Feb;53:67-73. doi: 10.1016/j.addbeh.2015.09.014. Epub 2015 Sep 25. PMID: 26454552. PMCID: PMC4699169. [Available on 2017-02-01]

Abstract: The current longitudinal study examined associations between interpersonal potentially traumatic events (PTEs; i.e., sexual or physical assault) and changes in alcohol consumption among incoming college students. Methods: 1197 students (68% female) participating in a university-wide research study were included in analyses. Assessments were administered at three time-points and included measures of alcohol use, PTEs (Life Events Checklist), and a screener for possible PTSD symptoms (abbreviated Primary Care PTSD Screen). Linear growth curve models were fit to the three repeated measures of alcohol quantity and frequency to determine the role of pre-college and college-onset interpersonal PTEs and possible PTSD symptoms on patterns of alcohol use. Results: Pre-college interpersonal PTE was associated with greater baseline alcohol use for female but not male students. College-onset interpersonal PTE predicted greater alcohol use at concurrent and future assessments for women but not men, beyond the effects of pre-college PTE. Pre-college possible PTSD symptoms did not predict baseline or change in alcohol use. Conclusions: There may be a stronger and longer-lasting impact of interpersonal PTE for college women compared to men on alcohol phenotypes, although replication in studies oversampling men endorsing interpersonal PTE is needed.

9.   Cho SB, Llaneza DC, Adkins AE, Cooke M, Kendler KS, Clark SL, Dick DM. Patterns of Substance Use Across the First Year of College and Associated Risk Factors. Frontiers in Psychiatry. 2015 Oct 27;6:152. doi: 10.3389/fpsyt.2015.00152. PMID: 26578984. PMCID: PMC4621385

Abstract: Starting college is a major life transition. This study aims to characterize patterns of substance use across a variety of substances across the first year of college and identify associated factors. We used data from the first cohort (N = 2056, 1240 females) of the “Spit for Science” sample, a study of incoming freshmen at a large urban university. Latent transition analysis was applied to alcohol, tobacco, cannabis, and other illicit drug uses measured at the beginning of the fall semester and midway through the spring semester. Covariates across multiple domains – including personality, drinking motivations and expectancy, high school delinquency, peer deviance, stressful events, and symptoms of depression and anxiety – were included to predict the patterns of substance use and transitions between patterns across the first year. At both the fall and spring semesters, we identified three subgroups of participants with patterns of substance use characterized as: (1) use of all four substances; (2) alcohol, tobacco, and cannabis use; and (3) overall low substance use. Patterns of substance use were highly stable across the first year of college: most students maintained their class membership from fall to spring, with just 7% of participants in the initial low substance users transitioning to spring alcohol, tobacco, and cannabis users. Most of the included covariates were predictive of the initial pattern of use, but covariates related to experiences across the first year of college were more predictive of the transition from the low to alcohol, tobacco, and cannabis user groups. Our results suggest that while there is an overall increase in alcohol use across all students, college students largely maintain their patterns of substance use across the first year. Risk factors experienced during the first year may be effective targets for preventing increases in substance use.

10.  Salvatore JE, Thomas NS, Cho SB, Adkins A, Kendler KS, Dick DM. The role of romantic relationship status in pathways of risk for emerging adult alcohol use. Psychology of Addictive Behaviors. 2016 May;30(3):335-44. doi: 10.1037/adb0000145. PMID: 27214170. PMCID: PMC4880412 [Available on 2017-05-01]

Abstract: Dating several people in emerging adulthood has been associated with higher alcohol use compared with being single or being in an exclusive relationship. As a follow-up to that report, we examined whether romantic relationship status is part of a pathway of risk between antecedent alcohol use risk factors and subsequent alcohol outcomes. Participants were 4,410 emerging adults assessed at 2 time-points during their first year of college. We found that a parental history of alcohol problems was indirectly related to dating several people via 2 modestly correlated pathways. The first pathway was through conduct problems. The second pathway was through positive urgency (i.e., a positive emotion-based predisposition to rash action). In turn, dating several people was associated with higher alcohol use. Our results suggest that these familial and individual-level alcohol risk factors are related to emerging adults' selection into subsequent romantic relationship experiences that are associated with higher alcohol use. These findings have implications for how romantic relationship experiences may fit into developmental models of the etiology of alcohol use.

11.  Berenz EC, Kevorkian S, Chowdhury N, Dick DM, Kendler KS, & Amstadter AB (2016). Posttraumatic stress disorder symptoms, anxiety sensitivity, and alcohol use motives in college students with a history of interpersonal trauma. Psychology of Addictive Behaviors, 30, 755-763.

Abstract: Posttraumatic stress disorder (PTSD) symptoms are associated with coping-motivated alcohol use in trauma-exposed samples. However, it is unclear which individuals experiencing PTSD symptoms are at greatest risk for alcohol-use problems following trauma exposure. Individuals endorsing high anxiety sensitivity, which is the fear of anxiety and related sensations, may be particularly motivated to use alcohol to cope with PTSD symptoms. In the current study, we examined the moderating role of anxiety sensitivity in the association between PTSD symptoms and coping motives in a sample of 295 young adults with a history of interpersonal trauma and current alcohol use. Participants completed measures of past 30-day alcohol consumption, trauma history, current PTSD symptoms, anxiety sensitivity, and alcohol-use motives. Results of hierarchical multiple regression analyses indicated that greater anxiety sensitivity was significantly associated with greater coping (β = .219) and conformity (β = .156) alcohol-use motives, and greater PTSD symptoms were associated with greater coping motives (β = .247), above and beyond the covariates of sex, alcohol consumption, trauma load, and noncriterion alcohol-use motives. The interaction of anxiety sensitivity and PTSD symptoms accounted for additional variance in coping motives above and beyond the main effects (β = .117), with greater PTSD symptoms being associated with greater coping motives among those high but not low in anxiety sensitivity. Assessment and treatment of PTSD symptoms and anxiety sensitivity in young adults with interpersonal trauma may be warranted as a means of decreasing alcohol-related risk in trauma-exposed young adults.

12.  Moore AA, Overstreet C, Kendler KS, Dick D, Adkins A, Amstadter AB. Potentially traumatic events, personality and risky sexual behavior in undergraduate college students. Psychological Trauma: Theory, Research, Practice, and Policy. 2016 Jun 27. doi: 10.1037/tra0000168. PMID: 27348066. [Epub ahead of print].

Abstract: Impulsivity and extraversion have demonstrated associations with risky sexual behavior (RSB) and potentially traumatic events (PTEs). In addition, interpersonal trauma appears to be associated with RSB, but research on the relationship between RSB and noninterpersonal PTEs (e.g., accidental) is lacking. The current study aims to investigate the relationships between personality (i.e., impulsivity, extraversion), RSB and multiple types of PTEs (i.e., accidental, physical, or sexual). Method: Personality and demographic characteristics were assessed during participants' (N = 970) first semester of college, past-12 month PTEs and RSB were assessed during the second semester of participants' junior year. Multiple linear regression was used to examine the relationship between PTEs, personality factors, and RSB. Analyses were also conducted to examine the potential mediating effect of interpersonal PTEs on the relationship between personality and RSB. Results: Impulsivity and extraversion were significantly positively associated with RSB. Both physical and sexual PTEs, but not accidental PTEs, were also significantly positively associated with RSB. Sexual PTEs significantly mediated the relationship between impulsivity and RSB. Conclusions: This is the first study to date to simultaneously examine the relationship between personality, RSB, and types of PTEs in a large sample of young adults. Exposure to interpersonal trauma appears to be a salient factor in the relationship between personality, specifically impulsivity, and RSB. These results indicate that college students may benefit from education regarding the potential negative outcomes of RSB, and that individuals with a history of interpersonal PTEs may be at increased risk for sexual risk taking.

13.  Cooke ME, Nasim A, Cho SB, Kendler KS, Clark SL, Dick DM. Predicting tobacco use across the first year of college. American Journal of Health Behaviors. 2016 Jul 40(4): 484-95. DOI:10.5993/AJHB.40.4.10

Abstract: The purpose of this study was to assess patterns of tobacco use across the first year of college, transitions in use, and associated predictors. Methods: The frequency of tobacco use (cigarettes, cigars, smokeless tobacco, and hookah) during the fall and spring of 4073 college students' first year at college were used as indicators in latent class (LCA) and latent transition analyses (LTA). Results: The LCA yielded 3 classes that represent levels of use frequency and not specific tobacco product classes: non-using, experimenting, and frequent using. The LTA results demonstrate stability in class membership from fall to spring. The most common transition was for the fall experimenters to transition out of experimentation. A series of demographic, environmental, and intrapersonal predictors were found to influence both fall class membership, and transitions from fall to spring. Conclusions: Students are likely to use multiple alternative tobacco products along with cigarettes. Their frequency of use of these products is fairly stable across the first year of college. Predictors reflecting experiences during the first year of college had the greatest impact on college tobacco use, demonstrating the importance of the college experience on young adult tobacco use.

14.  Bono R, Barnes A, Dick DM, Kendler KS. Drinking, Cigarette Smoking, and Employment among American College Freshmen at a Four-Year University. Substance Use and Misuse. 2016 Oct 18:1-12. [Epub ahead of print] doi: 10.1080/10826084.2016.1223136. PubMed PMID: 27754728

Abstract: For American college students, alcohol and cigarette use are important health concerns, and employment concurrent with school attendance is on the rise. Given the lifelong importance of employment and substance use trajectories begun in college, parsing out the relationship between the two is meaningful. Objective: This study's purpose is to determine whether employment during college is associated with substance use. Methods: Cross-sectional associations between employment (work hours, earnings) and substance use (drinking frequency, drinking quantity, smoking frequency) were estimated using partial proportional odds models in a sample of N = 1457 freshmen attending a large, public 4-year university in 2011, after accounting for demographics, personality, social environment, and parental influences. Results: Working 10 more hours and earning $50 more per week as a freshman had modest positive associations with higher smoking frequency and with moderate drinking frequency and quantity prior to adjustment. After adjustment, work hours remained modestly associated with moderate drinking frequency and quantity. No adjusted associations were found among employment measures and smoking or between weekly earnings and drinking frequency. Different relationships emerged for moderate versus heavy alcohol use frequency and quantity. Conclusions: Both employment and substance use are commonplace among college freshmen. After extensive controls for potential confounders, the relationship between the two appears modest. Employment may yet play a role in college student substance use, but work hours and earnings are likely only small parts of a larger web of influences on drinking and smoking.

15.  Homman LE, Edwards AC, Cho SB, Dick DM, Kendler KS. Gender and direction of effect of alcohol problems and internalising symptoms in a longitudinal sample of college students. Substance Use and Misuse. Epub 2016 Nov 16. doi: 10.1080/10826084.2016.1233983

Abstract: Alcohol problems and internalizing symptoms are consistently found to be associated but how they relate to each other is unclear. Objective: The present study aimed to address limitations in the literature of comorbidity of alcohol problems and internalizing symptoms by investigating the direction of effect between the phenotypes and possible gender differences in college students. Method: We utilized data from a large longitudinal study of college students from the United States (N = 2607). Three waves of questionnaire-based data were collected over the first two years of college (in 2011–2013). Cross-lagged models were applied to examine the possible direction of effect of internalizing symptoms and alcohol problems. Possible effects of gender were investigated using multigroup modeling. Results:There were significant correlations between alcohol problems and internalizing symptoms. A direction of effect was found between alcohol problems and internalizing symptoms but differed between genders. A unidirectional relationship varying with age was identified for males where alcohol problems initially predicted internalizing symptoms followed by internalizing symptoms predicting alcohol problems. For females, a unidirectional relationship existed wherein alcohol problems predicted internalizing symptoms. Conclusions/Importance: We conclude that the relationship between alcohol problems and internalizing symptoms is complex and differ between genders. In males, both phenotypes are predictive of each other, while in females the relationship is driven by alcohol problems. Importantly, our study examines a population-based sample, revealing that the observed relationships between alcohol problems and internalizing symptoms are not limited to individuals with clinically diagnosed mental health or substance use problems.

16. Bryant N, Arendt J, Kendler KS, Dick DM, Adkins A. From saliva samples to the classroom and beyond: What college students are telling us about genetic and environmental influences on substance use and emotional health. Substance Abuse Library and Information Studies (2016) Volume III, Issue I. Pg. 4-10

Abstract: In 2011, researchers at Virginia Commonwealth University launched “Spit for Science,” a large-scale longitudinal study in which nearly 9,900 undergraduate students are currently enrolled. Students will be followed across their college years and beyond to understand how genetic and environmental factors influence substance use and emotional health over time. This presentation highlights several facets of the project. A collaboration between a researcher and an interdisciplinary team of librarians demonstrates how the data are being integrated into the classroom to enhance undergraduate students’ understanding of the research process. We also discuss multidisciplinary collaborations that have evolved from the project as well as the DNA component, including work in progress and work that remains. If replicated at other universities, this model holds promise for better understanding the associations between genes and substance use and mental health disorders.

17.  Overstreet CM, Berenz EC, Kendler KS, Dick DM, Amstadter AB. Predictors and mental health outcomes of potentially traumatic event exposure. Psychiatry Research (2017) Volume 247, Pages 296-304 doi: 10.1016/j.psychres.2016.10.047

Abstract: The aims were two-fold: to examine prevalence and correlates of lifetime potentially traumatic event (PTE) exposure and to explore the relationships between PTE exposure and mental health outcomes (i.e., trauma related distress, alcohol use quantity and frequency, depression symptoms, and anxiety symptoms) within a large sample of college freshmen. 6120 participants, consisting of three cohorts of incoming freshman at a large southeastern university, completed an online assessment battery measuring a multitude of factors including PTEs, personality, relationships (i.e., parental and peer), and mental health. The majority (81.8%) of participants endorsed experiencing at least one PTE within their lifetime and 39.0% reported at least one interpersonal trauma (i.e., physical assault, sexual assault, other unwanted or uncomfortable sexual situation). The average number of PTE categories endorsed was 1.71 (SD=1.30), and 8.7% of participants reported experiencing four or more separate PTE categories pre-college entry. Female gender and peer deviance were consistently associated with PTE exposure and symptoms of psychopathology. Furthermore, a history of interpersonal PTE exposure was associated with increased alcohol use (i.e., frequency and quantity), trauma related distress, depressive symptoms, and anxiety symptoms. The data demonstrate high prevalence PTE exposure among young adults and the clinical significance of a PTE history.

18.  Spindle T, HIler M, Cooke M, Eissenberg T, Kendler KS, Dick DM. Electronic cigarette use and uptake of cigarette smoking: A longitudinal examination of US college students. Addictive Behaviors, in press.

Abstract: Introduction: Electronic cigarette (e-cigarette) use prevalence is increasing among U.S. adolescents and adults but recent longitudinal data for college/university students are scarce. Furthermore, the extent that e-cigarette use is associated with the onset of cigarette smoking and the factors that lead to the uptake of e-cigarettes in college students has not been explored. Methods: 3757 participants from a Mid-Atlantic university (women: 66%; White: 45%; Black: 21%; Asian: 19%; Hispanic/Latino: 6%) were surveyed in 2014 and again in 2015. Results: Among participants reporting never smoking at time 1, those who had ever tried e-cigarettes or were currently using e-cigarettes (at least one use in past 30days) were more likely to have ever tried cigarettes by time 2 relative to individuals who had not used e-cigarettes. Ever use of e-cigarettes (but not current use) also increased participants' likelihood of being current cigarette smokers at time 2. Among initial never users of e-cigarettes or cigarettes, males and ever marijuana users had an increased probability of trying e-cigarettes by time 2. Furthermore, less perseverance (an index of impulsivity) and ever use of other tobacco products increased initial never users' chances of trying both cigarettes and e-cigarettes by time 2. Conclusions: Given that never-smoking participants who had tried e-cigarettes were more likely to initiate cigarette use later, limiting young adults' access to these products may be beneficial. As the long-term health implications of e-cigarette use become clearer, predictors of e-cigarette use could help identify future populations likely to use and abuse these products.

19. Lind MJ, Baylor A, Overstreet CM, Hawn SE, Rybarczyk BD, Kendler KS, Dick DM, Amstadter AB. Relationships between potentially traumatic events, sleep disturbance, and symptoms of PTSD and alcohol use disorder in a young adult sample. Sleep Medicine(2017) Volume 34, Pages 141-147 doi: 10.1016/j.sleep.2017.02.024.

Abstract: Traumatic events, particularly those that are interpersonal in nature, are associated with increased risk for co-occurring sequelae, including sleep disturbances, posttraumatic stress disorder (PTSD), and alcohol use disorder (AUD). However, the associations between these phenotypes have not been explored among college students. Methods: We examined relationships between type of potentially traumatic event (PTE) exposure (pre-college) and sleep disturbances, as well as mediating effects of lifetime PTSD and AUD symptoms on these relationships, in a large undergraduate sample (N = 1599, 64.7% female). Hierarchical linear regressions were conducted, beginning with demographics and then adding interpersonal and accidental PTEs in a stepwise regression; mediation analyses were run. Results: Within the sample, 33.7% endorsed at least one interpersonal PTE, while 64.4% endorsed at least one accidental PTE. Hierarchical regressions demonstrated that interpersonal (β = 0.202, p = 0.000), but not accidental PTE exposure significantly predicted disturbed sleep. Both PTSD and AUD symptoms significantly mediated (p values < 0.001) the relationship between interpersonal PTE exposure and sleep, with indirect effects accounting for 61% and 17% of total effects, respectively. In the correlated mediation model, both disorders remained significant mediators (p < 0.001), with indirect effects accounting for 56% (PTSD symptoms) and 14% (AUD symptoms) of total effects on sleep. Conclusions: Results suggest that interpersonal PTEs are more potent predictors of sleep problems than accidental PTEs. Further, trauma exposure psychiatric symptom sequelae (PTSD, AUD) account for part of the relationship between interpersonal PTE exposure and disturbed sleep, which both independently and jointly suggests that treating PTSD and AUD symptoms in college students may also improve sleep.

20.  O’Shea T, Thomas NS, Webb BT, Dick DM, Kendler KS, & Chartier, KG. ALDH2 rs671 and peer drinking in East Asian college students.  The American Journal of Drug and Alcohol Abuse, (2017) Epub ahead of print

Abstract: The ALDH2*2 allele (A-allele) at rs671 is more commonly carried by Asians and is associated with alcohol-related flushing, a strong adverse reaction to alcohol that is protective against drinking. Social factors, such as having friends who binge drink, also contribute to drinking in Asian youth. Objective:  This study examined the interplay between ALDH2*2, peer drinking, and alcohol consumption in college students. We hypothesized that the relationship between ALDH2*2 and standard grams of ethanol per month would vary based on the level of peer drinking. Methods:  Subjects (N = 318, 63.25% female) were East Asian college students in the United States who reported drinking alcohol. Data were from the freshman year of a university survey that included a saliva DNA sample. ALDH2*2 status was coded ALDH2*2(+) (A/G and A/A genotypes) and ALDH2*2(-) (G/G genotype). Peer drinking was students' perception of how many of their friends "got drunk". Results: Main effects of ALDH2*2(-) and having more friends who got drunk were associated with greater alcohol consumption. The ALDH2*2 × peer drunkenness interaction showed a stronger positive association with alcohol consumption for ALDH2*2(-) versus ALDH2*2(+) at increasing levels of peer drunkenness. Follow-up comparisons within each peer drunkenness level identified significantly higher alcohol consumption for ALDH2*2(-) compared to ALDH2*2(+) at the all friends got drunk level. Conclusion: There was evidence of a stronger effect for ALDH2*2(-) compared to ALDH2*2(+) with greater alcohol use when students were more exposed to peer drinking. Findings contribute to a growing literature on the interrelationships between genetic influences and more permissive environments for alcohol consumption.

21. Peterson RE, Edwards AC, Bacanu SA, Dick DM, Kendler KS, Webb BT. The Utility of empirically assigning ancestry groups in cross-population genetic studies of addiction. Am J Addict (2017) 26(5) 494-501 doi: 10.1111/ajad.12586.

Abstract: Given moderate heritability and significant heterogeneity among addiction phenotypes, successful genome-wide association studies (GWAS) are expected to need very large samples. As sample sizes grow, so can genetic diversity leading to challenges in analyzing these data. Methods for empirically assigning individuals to genetically informed ancestry groups are needed. Methods:  We describe a strategy for empirically assigning ancestry groups in ethnically diverse GWAS data including extensions of principal component analysis (PCA) and population matching through minimum Mahalanobis distance. We apply these methods to data from Spit for Science (S4S): the University Student Survey, a study following college students longitudinally that includes genetic and environmental data on substance use and mental health (n = 7,603).

22. Soneji S., Barrington-Trimis JL, Wills TA, Leventhal AM, Unger JB, Gibson LA, Yang J, Primack BA, Andrews JA, Miech TA, Spindle TR, Dick DM, Eissenberg T, Hornik RC, Dang T, Sargent JD. (2017). Association Between Initial Use of e-Cigarettes and Subsequent Cigarette Smoking Among Adolescents and Young Adults A Systematic Review and Meta-analysis. JAMA Pediatr. 171(8) 788-797, doi: 10.1001/jamapediatrics.2017.1488.

Abstract: To perform a systematic review and meta-analysis of longitudinal studies that assessed initial use of e-cigarettes and subsequent cigarette smoking. DATA SOURCES: PubMed, EMBASE, Cochrane Library, Web of Science, the 2016 Society for Research on Nicotine and Tobacco 22nd Annual Meeting abstracts, the 2016 Society of Behavioral Medicine 37th Annual Meeting & Scientific Sessions abstracts, and the 2016 National Institutes of Health Tobacco Regulatory Science Program Conference were searched between February 7 and February 17, 2017. The search included indexed terms and text words to capture concepts associated with e-cigarettes and traditional cigarettes in articles published from database inception to the date of the search. STUDY SELECTION: Longitudinal studies reporting odds ratios for cigarette smoking initiation associated with ever use of e-cigarettes or past 30-day cigarette smoking associated with past 30-day e-cigarette use. Searches yielded 6959 unique studies, of which 9 met inclusion criteria (comprising 17 389 adolescents and young adults).DATA EXTRACTION AND SYNTHESIS: Study quality and risk of bias were assessed using the Newcastle-Ottawa Scale and the Risk of Bias in Non-randomized Studies of Interventions tool, respectively. Data and estimates were pooled using random-effects meta-analysis. MAIN OUTCOMES AND MEASURES: Among baseline never cigarette smokers, cigarette smoking initiation between baseline and follow-up. Among baseline non-past 30-day cigarette smokers who were past 30-day e-cigarette users, past 30-day cigarette smoking at follow-up. RESULTS: Among 17 389 adolescents and young adults, the ages ranged between 14 and 30 years at baseline, and 56.0% were female. The pooled probabilities of cigarette smoking initiation were 30.4% for baseline ever e-cigarette users and 7.9% for baseline never e-cigarette users. The pooled probabilities of past 30-day cigarette smoking at follow-up were 21.5% for baseline past 30-day e-cigarette users and 4.6% for baseline non-past 30-day e-cigarette users. Adjusting for known demographic, psychosocial, and behavioral risk factors for cigarette smoking, the pooled odds ratio for subsequent cigarette smoking initiation was 3.62 (95% CI, 2.42-5.41) for ever vs never e-cigarette users, and the pooled odds ratio for past 30-day cigarette smoking at follow-up was 4.28 (95% CI, 2.52-7.27) for past 30-day e-cigarette vs non-past 30-day e-cigarette users at baseline. A moderate level of heterogeneity was observed among studies (I2 = 60.1%). CONCLUSIONS AND RELEVANCE: e-Cigarette use was associated with greater risk for subsequent cigarette smoking initiation and past 30-day cigarette smoking. Strong e-cigarette regulation could potentially curb use among youth and possibly limit the future population-level burden of cigarette smoking.

23Cooke, M. E., Neale, Z. E., Barr, P. B., Myers, J., Dick, D. M., Kendler, K. S., & Edwards, A. C. (2017). The Role of Social, Familial, and Individual‐Level Factors on Multiple Alcohol Use Outcomes During the First Year of University. Alcoholism: clinical and experimental research, 41(10), 1783-1793.

Abstract: The first year of university attendance represents a critical time frame for the development of alcohol use and misuse given changes in autonomy and increased access to alcohol. Prior studies have demonstrated that the establishment of drinking patterns during this period is impacted by an array of demographic, environmental, and familial factors. It is critical to consider such factors jointly, and to understand potentially differential effects on stages of alcohol use/misuse, in order to identify robust predictors that may be targeted in prevention and intervention programming. METHODS: As part of a longitudinal study, students at a large, public U.S. university were invited to complete online surveys that included questions related to alcohol use, emotional and behavioral health, environmental factors, sociodemographic factors, and familial environment. This study uses data from surveys administered in the fall and spring of the first year of university. We used univariate (maximum N = 7,291) and multivariate (maximum N = 4,788) logistic and linear regressions to evaluate the associations between potential risk and protective factors with 4 alcohol use outcomes: initiation, consumption, problems, and addiction resistance. RESULTSIn multivariate models, we observed associations between demographic, social/environmental, and personal-level predictors with all 4 alcohol outcomes, several of which were consistent across each stage of alcohol use. A deviant high school peer group was one of the strongest predictors of risk across outcomes. The influence of drinking motives and alcohol expectancies varied by alcohol use outcome. Externalizing characteristics were associated with increased risk across outcomes, while internalizing symptoms were associated with more problems and lower addiction resistance. CONCLUSIONSThese findings underscore the complex network of factors influencing stages of alcohol use during the first year of university. Importantly, these findings demonstrate that the impact of predictors changes across stages of alcohol use/misuse, which presents opportunities for targeted prevention efforts. 

24.Docherty, A., Moscati, A., Savage, J., Salvatore, J., Cooke, M., Aliev, F., ... & Adkins, D. (2017). Genome-Wide Polygenic Atlas of The Phenome In Emerging Adulthood: Genetic Overlap of Risk Across Five Ancestries. European Neuropsychopharmacology, 27, S400-S401.

Abstract: Identifying genetic relationships between complex traits in emerging adulthood can provide useful etiological insights into risk for psychopathology. College-age individuals are under-represented in genomic analyses thus far, and the majority of work has focused on the clinical disorder or cognitive abilities rather than normal-range behavioral outcomes. METHODS: This study examined a sample of emerging adults 18-22 years of age (N = 5947) to construct an atlas of polygenic risk for 33 traits predicting relevant phenotypic outcomes. Twenty-eight hypotheses were tested based on the previous literature on samples of European ancestry, and the availability of rich assessment data allowed for polygenic predictions across 55 psychological and medical phenotypes. RESULTS: Polygenic risk for schizophrenia (SZ) in emerging adults predicted anxiety, depression, nicotine use, trauma, and family history of psychological disorders. Polygenic risk for neuroticism predicted anxiety, depression, phobia, panic, neuroticism, and was correlated with polygenic risk for cardiovascular disease.CONCLUSIONS: These results demonstrate the extensive impact of genetic risk for SZ, neuroticism, and major depression on a range of health outcomes in early adulthood. Minimal cross-ancestry replication of these phenomic patterns of polygenic influence underscores the need for more genome-wide association studies of non-European populations.

25. Webb, B.T., Edwards, A.C., Wolen, A.R., Salvatore, J.E., Aliev, F., Riley, B.P., Sun, C., Williamson, V.S., Kitchens, J.N., Pedersen, K. and Adkins, A., 2017. Molecular genetic influences on normative and problematic alcohol use in a population-based sample of college students. Frontiers in genetics, 8, p.30. 

Abstract: Genetic factors impact alcohol use behaviors and these factors may become increasingly evident during emerging adulthood. Examination of the effects of individual variants as well as aggregate genetic variation can clarify mechanisms underlying risk. Methods: We conducted genome-wide association studies (GWAS) in an ethnically diverse sample of college students for three quantitative outcomes including typical monthly alcohol consumption, alcohol problems, and maximum number of drinks in 24 h. Heritability based on common genetic variants (h2SNP) was assessed. We also evaluated whether risk variants in aggregate were associated with alcohol use outcomes in an independent sample of young adults. Results: Two genome-wide significant markers were observed: rs11201929 in GRID1 for maximum drinks in 24 h, with supportive evidence across all ancestry groups; and rs73317305 in SAMD12 (alcohol problems), tested only in the African ancestry group. The h2SNP estimate was 0.19 (SE = 0.11) for consumption, and was non-significant for other outcomes. Genome-wide polygenic scores were significantly associated with alcohol outcomes in an independent sample. Conclusions: These results robustly identify genetic risk for alcohol use outcomes at the variant level and in aggregate. We confirm prior evidence that genetic variation in GRID1 impacts alcohol use, and identify novel loci of interest for multiple alcohol outcomes in emerging adults. These findings indicate that genetic variation influencing normative and problematic alcohol use is, to some extent, convergent across ancestry groups. Studying college populations represents a promising avenue by which to obtain large, diverse samples for gene identification.

26. Niazi Z, Dick DM, Adkins A, Cooke M. The influence of parenting styles on alcohol and nicotine drug use among university students. (2017). Am Journal of Undergraduate Research, 14(3). 37.

ABSTRACT: Parenting styles are important in the behavioral development of adolescents. The environment created by the parent, in regards to communication with their child and level of independence given to their child, may influence the child’s susceptibility to risk behaviors. This study examines the relationship between parenting style and substance use among university students. We hypothesized that university students exposed to lower levels of autonomy granting (AG) or parental involvement (PI) parenting styles would have an increased likelihood of alcohol and nicotine use. We also hypothesized that religiosity, parental education level, ethnicity, and gender would act as moderators of parenting styles and alcohol and nicotine use. Data from a diverse university-wide sample was collected in the fall semester of the student’s freshman year from 2011-2014 (N = 9889, 61.5% female). Results demonstrated that AG had a significant, negative association with alcohol use (B = -0.033, p = 0.006) and nicotine use (B = -0.066, p <0.001). All moderators were found to be significant predictors of alcohol use, however only father education level demonstrated a borderline significant moderation of the relationship between PI and alcohol use. Religiosity, Black race, Asian race, and gender were found to be significant predictors of nicotine use. Only gender moderated the association between PI and nicotine use. Even though alcohol and nicotine use and AG were associated, our results indicate that once students enter university, previous parenting style does not have a strong effect on alcohol and nicotine use behaviors in our sample.

27. Bares, C.B., Dick, D., Kendler, K.S. (2018). Nicotine dependence, internalizing symptoms, mood variability and daily tobacco use among young adult smokers. Addictive Behaviors: Special Issue on Ambulatory Assessment. 83:87-94. doi: 10.1016/j.addbeh.2017.09.004.

Abstract: Tobacco use among college aged young adults continues to rise.  Previous studies have suggested a bidirectional relationship between internalizing symptoms, mood variability and tobacco use.  Examining the association of within-individual differences in negative mood and cigarette use, while controlling for the influence of internalizing symptoms, could provide a test regarding the direction of causation between internalizing symptoms and cigarette use. Methods: Data for this study came from a sample of college students (n=39, 59% female, mean age 20.4 years) who reported regular tobacco cigarette use and participated in a 21-day ecological momentary assessment (EMA) study assessing cigarette use and mood. Results: A three-level hierarchical linear model accounting for the structure of 1,896 occasions of cigarette use nested within days and individuals indicated that within-individual variability in negative mood was associated with smoking more cigarettes at each occasion, after taking into account the influence of internalizing symptoms and nicotine dependence. Conclusions: Negative mood variability might be indexing an occasion-level measure of internalizing symptoms that varies within individuals and leads to consuming more cigarettes.

28. Chowdhury, N., Kevorkian, S., Hawn, S.E., Amstadter, A.B., Dick, D., Kendler, K.S., Berenz, E.C. (2018). Associations between personality and distress tolerance among trauma-exposed young adults. Personality and Individual Differences, 120, 166-170.

Abstract: Low distress tolerance (DT) is related to negative mental health outcomes, particularly among trauma-exposed populations, who are at greater risk for mental health problems. However, little is known about potential etiological factors underlying the development of perceived (i.e., self-report) or behaviorally assessed DT. The present study examined associations between Big Five personality factors (i.e., openness, conscientiousness, extraversion, agreeableness, & neuroticism) and multiple measures of DT. Participants were 440 college students (71.4% women) endorsing a history of one or more potentially traumatic events. Participants completed the abbreviated Big Five Inventory (BFI), Distress Tolerance Scale (DTS), Discomfort Intolerance Scale (DIS), breath-holding task, and Paced Auditory Serial Addition Test (PASAT). Results of a series of hierarchical linear regressions indicated that higher levels of neuroticism and lower levels of conscientiousness were significantly associated with lower DTS scores, but no other DT measures. Greater extraversion was significantly associated with greater DT on the DIS and was nominally associated with greater DT on the PASAT. Lower levels of openness were associated with lower DT on the breath-holding task. Individual differences in normal personality traits account for significant variation in multiple measures of DT and may provide insight into the etiology of various forms of DT.

29. Barker SB, Schubert CM, Barker RT, Kuo SI, Kendler KS & Dick DM (2018). The relationship between pet ownership, social support, and internalizing symptoms in students from the first to fourth year of college. Journal of Applied Developmental Science. DOI: 10.1080/10888691.2018.1476148

Abstract: Internalizing symptoms are prevalent in students as they enter and complete college. Considering research suggesting mental health benefits of pet ownership, this study explores the relationship between pet ownership, social support (SS), and internalizing symptoms (IS) in a cohort of students across their 4-year college experience. With no differences at college entry, students growing up with pets had greater IS through the fourth year, and greater SS through the third year, than those without pets. Currently living with a pet, gender, SS and personality predicted IS in the fourth year. Females experiencing higher IS in their first year are more likely to live with pets in their fourth year, and fourth year females living with pets or greatly missing absent pets have higher IS than females without pets or missing pets less. Findings suggest a unique relationship between IS in female students and their pet relationships not seen in males.

30. Neale, Z. E., Salvatore, J. E., Cooke, M. E., Savage, J. E., Aliev, F., Donovan, K. K., ... & Dick, D. (2018). The Utility of a Brief Web-based Prevention Intervention as a Universal Approach for Risky Alcohol Use in College Students: Evidence of Moderation by Family History. Frontiers in Psychology, 9, 747.

Abstract: Alcohol use on college campuses is prevalent and contributes to problems that affect the health, emotional wellbeing, and academic success of college students. Risk factors, such as family history of alcohol problems, predict future alcohol problems, but less is known about their potential impact on intervention effectiveness. The purpose of this study was to examine the effect of an intervention implemented in a non-randomized sample of drinking and non-drinking college freshmen. Methods: Freshmen college students recruited for the intervention study (n = 153) completed a web-adaptation of the Brief Alcohol Screening and Intervention for College Students (BASICS) at the start of spring semester. We compared their 30-days post-intervention alcohol initiation, number of drinking days (DAYS), drinks per occasion (DRINKS), maximum drinks in 24 h (MAX24) and alcohol use disorder symptoms (AUDsx) to 151 comparison participants retrospectively matched on demographics and baseline alcohol use behaviors. We also tested baseline DRINKS, DAYS, AUDsx, MAX24, and parental family history (PFH) of alcohol problems as moderators of the effect of the intervention. Results: At follow-up, intervention participants had lower rates of AUDsx than comparison participants, especially among baseline drinkers. Among participants drinking 3+ days/month at baseline, intervention participants showed fewer DAYS at follow-up than the comparison group participants. BASICS was also associated with a decreased likelihood of initiation among baseline non-drinkers. PFH significantly interacted with treatment group, with positive PFH intervention participants reporting significantly fewer AUDsx at follow-up compared to positive PFH comparison participants. We found no evidence for an effect of the intervention on DRINKS or MAX24 in our analyses. Conclusions: Results suggest some indication that novel groups, such as non-drinkers, regular drinkers, and PFH positive students may experience benefits from BASICS. Although conclusions were limited by lack of randomization and short follow-up period, PFH positive and low to moderate drinking groups represent viable targets for future randomized studies. 

31. Berenz, E. C., McNett, S., Rappaport, L., Vujanovic, A. A., Viana, A. G., Dick, D., & Amstadter, A. B. (in press). Age of alcohol use initiation and psychiatric symptoms among young adult trauma survivors. Addictive Behaviors. 88: 150-156. doi: 10.1016/j.addbeh.2018.08.022

Abstract: Alcohol use disorder (AUD) evidences high rates of comorbidity with a range of psychiatric disorders, particularly within high-risk populations, such as individuals exposed to physical or sexual violence. Increasing efforts are focused on understanding the role of early alcohol use (e.g., during adolescence) on emotional and psychiatric functioning over time, as well as sex differences in these associations. The aim of the current study was to evaluate patterns of association between age of initiation of regular alcohol use and posttraumatic stress disorder (PTSD), anxiety, and depressive symptoms as a function of sex. Participants were 269 college students with a history of interpersonal trauma and alcohol use who completed a battery of questionnaires regarding alcohol use and emotional health. Neither bivariate correlations nor results from structural equation models covarying for key factors showed a relationship between age of alcohol use initiation and current psychiatric symptoms among men (n = 63). Results of a structural equation model supported an association between earlier age of alcohol use initiation and greater levels of current PTSD (β = -0.14), anxiety (β = -0.15), and depression symptoms (β = -0.16) in the female sub-sample (n = 202), after controlling for covariates, as well as intercorrelations among criterion variables. Statistical support for sex as a moderator of these associations was not detected. The current study provides preliminary evidence for potential sex differences in the role of early alcohol use in the development of psychiatric symptoms and highlights the need for systematic longitudinal research. 

32. Williams K, Thomas NS, Adkins AE, Dick DM. (2018) Perception of peer drinking and access to alcohol mediate the effect of residence status on alcohol consumption. American Journal of Undergraduate Research, 13-21, 14(4)

Abstract: Alcohol consumption is common in college attending populations, and can have a negative impact on an individual's academic, physical, and mental health. Previous research suggests that living at home could act as a protective measure. The current research looks at potential mediators of the association between living with parents while attending college and amount of alcohol consumed. In particular, we examined access to alcohol, parental monitoring, and perception of peer drunkenness as mediators of the association.  Methods: This study examined freshman data collected from a survey conducted at a large public university in the mid-Atlantic United States.  A pathway model was fit to test the relationships between residence status, access to alcohol, parental monitoring, and perception of peer drunkenness on alcohol consumption. Results:  We observed statistically significant indirect effects of residence status on alcohol consumption through perception of peer drinking and access to alcohol. Parental monitoring was significantly related to lower alcohol consumption and there was a direct effect of residence status on alcohol consumption.   Conclusion: There were significant indirect effects of residence status on alcohol consumption through both peer drinking and access to alcohol. Parental monitoring was associated with decreased alcohol consumption, with no indirect effect in association with residence status. These effects were persistent in the presence of a range of covariates, including age, gender, ethnicity, and parental education. 

33. Su J, Hancock L, McGann A, Alshagra M, Ericson R, Niazi Z, Dick DM, Adkins A. (2018) Evaluation of the impact of campus-wide social norms marketing intervention on alcohol use perceptions, consumption and blackouts. J Am Coll Health, 66(3);219-224. doi: 10.1080/07448481.2017.1382500.

Abstract:  To evaluate the effect of a campus-wide social norms marketing intervention on alcohol-use perceptions, consumption, and blackouts at a large, urban, public university. PARTICIPANTS: 4,172 college students (1,208 freshmen, 1,159 sophomores, 953 juniors, and 852 seniors) who completed surveys in Spring 2015 for the Spit for Science Study, a longitudinal study of students' substance use and emotional health. METHODS: Participants were e-mailed an online survey that queried campaign readership, perception of peer alcohol use, alcohol consumption, frequency of consumption, and frequency of blackouts. Associations between variables were evaluated using path analysis. RESULTS: We found that campaign readership was associated with more accurate perceptions of peer alcohol use, which, in turn, was associated with self-reported lower number of drinks per sitting and experiencing fewer blackouts. CONCLUSIONS: This evaluation supports the use of social norms marketing as a population-level intervention to correct alcohol-use misperceptions and reduce blackouts.

34. Hawn SE, Lind, MJ, Conley A, Overstreet, CM, Kendler KS, Dick DM, Amstadter AB. (2018) Effects of social support on the association between pre-college sexual assault and college onset victimizationJ Am Coll Health, 66(6): 467-475. doi: 10.1080/07448481.2018.1431911.

Abstract:  This study examined the moderating and mediating effects of perceived social support on the association between precollege sexual assault (SA) and college-onset SA.PARTICIPANTS: A representative sample of 6,132 undergraduates. METHODS: The PLUM procedure in SPSS was used to test the moderation model, with individual regressions conducted in a hierarchical fashion. A weighted least squared mean and variance adjusted (WLSMV) mediation model was used to examine the mediating effect of social support. RESULTS: Precollege SA significantly predicted college-onset SA. Social support significantly mediated the relation between precollege SA and college-onset SA. Social support was not a significant moderator of this relationship. CONCLUSIONS: Given the high prevalence of SA among college populations, as well as the high rates of SA revictimization, identification of factors that may be related to repeated SA (eg, low social support) within this population are essential and may inform intervention, policy, and university student services.

35. Bourdon JL, Moore AA, Long EC, Kendler KS, Dick DM. (2018) The relationship between on-campus service utilization and common mental health symptoms in undergraduate college students. Psycholo Serv doi: 10.1037/ser0000296.

Abstract: Little research exists into the trends associated with on-campus service utilization for mental health concerns of college students. Rates of broad service utilization exist, but no published study has examined the direct relationship between a range of common mental health symptoms and on-campus service utilization. The aims of the present study are to explore (1) which common mental health concerns are associated with specific on-campus service utilization in undergraduate students and (2) whether endorsement of more mental health concerns will predict a higher number of services utilized. Data were utilized from 3,734 undergraduates at a large (more than 20,000 undergraduates), urban university (Mage = 19.94 years, SD = 0.55 years; female = 66%). Four on-campus services (University Counseling Services, University Health Services, The Wellness Resource Center, and Disability Support Services) were regressed onto mental health concerns associated with symptoms of three disorders (anxiety, depression, alcohol use disorder [AUD]) and two mental health risk factors (stressful life events [SLEs], antisocial behaviors [ASBs]). AUD symptoms predicted the most overall and specific service utilization, followed by depression symptoms and SLEs. Anxiety symptoms and ASBs were not significant predictors when combined with other variables. This is the first study to investigate trends specific to on-campus college student service utilization. Findings will be helpful to mental health professionals on similar college campuses by providing insight into programming and outreach initiatives for these or related services.

36. Do EK, Prom-Wormley EC, Fuemmeler BF, Dick DM, Kendler KS & Maes HH. (2018) Associations Between Initial Subjective Experiences with Tobacco and Self-Reported Recent Use in Young Adulthood Subst Use Misuse, 53(14): 2291-2298. doi: 10.1080/10826084.2018.1473435.

ABSTRACT: Youth tobacco use behaviors are predictive of patterns in adulthood and effect long-term health outcomes. Yet, few studies have examined the effect of initial subjective experiences (ISEs) during first tobacco use, which has been found to be an indicator of individuals. sensitivity to nicotine and vulnerability to dependence. OBJECTIVE: The present study aimed to determine the prevalence of ISEs across a variety of tobacco products, evaluate the factor structure of ISEs by first tobacco product used, and examine the relationship between ISEs and recent (30-day) use of tobacco products across time, using a university sample. METHODS: Exploratory factor analyses were conducted to identify latent factors present with respect to items measuring ISEs with tobacco, separately by tobacco product (e.g. cigarettes, cigars, hookah, e-cigarettes). Factor scores for positive and negative ISEs were calculated. Multiple logistic regression analyses were conducted to examine associations between ISEs and recent use of each tobacco product, adjusted for age at first use, sex, race/ethnicity, and cohort. RESULTS: ISEs differ by the first tobacco product used. Associations between factor scores for positive and negative ISEs and recent use were found across a variety of tobacco products. Overall, positive ISEs were more strongly associated with recent use, relative to negative ISEs. CONCLUSIONS: Further research is needed to identify genetic and biological pathways and social contexts influencing initial subjective experiences with tobacco use, in efforts to delay the initiation for tobacco use and reduce risk for continued use among young adults.

37. Hawn SE,  Sheerin CM, Webb BT, Peterson RE, Do E, Dick, DM, Kendler KS, Bacanu SA, Amstadter AB. Replication of the interaction of PRKG1 and trauma exposure on alcohol misuse in an independent, African American sample. (2018). J Trauma Stress 31(6): 927-932 doi: 10.1002/jts.22339

Abstract: In the present study, we sought to replicate recent findings of Polimanti et al. (2017), who conducted a genome-wide gene-by-environment interaction study (GEWIS) and identified a gene-by-trauma interaction that predicts alcohol misuse among African Americans.  Consistent with the findings published by Polimanti and colleagues, results of the current study demonstrated an interaction effect, b = 0.41, of trauma exposure and rs1729578 in the intron of PRKG1 on alcohol misuse in a subsample of ancestral African Americans. The minor allele (rs1729578*C) was positively associated with increased alcohol use disorder symptoms in trauma-exposed subjects and negatively associated in non-trauma-exposed subjects.  This effect, however, was only significant for one out of three alcohol outcome measures we investigated, suggesting the interaction may be most salient when predicting higher severity of alcohol misuse. Additionally, the effect did not remain significant after we accounted for testing the effect on three different outcome variables. Also in line with the original study, the gene-by-environment effect was not demonstrated among the ancestral European subsample.  The findings suggest this gene variant may increase an individual's susceptibility to environmental influences, both adverse and supportive.

38. Savage JE, Jansen PR, Stringer S, et al. GWAS meta-analysis identifies new genes and functional links to intelligence (N=279,930) (2018). Nat Genet 50(7):912-919. doi: 10.1038/s41588-018-0152-6. 

Abstract: Intelligence is highly heritable1 and a major determinant of human health and well-being2. Recent genome-wide meta-analyses have identified 24 genomic loci linked to variation in intelligence3-7, but much about its genetic underpinnings remains to be discovered. Here, we present a large-scale genetic association study of intelligence (n = 269,867), identifying 205 associated genomic loci (190 new) and 1,016 genes (939 new) via positional mapping, expression quantitative trait locus (eQTL) mapping, chromatin interaction mapping, and gene-based association analysis. We find enrichment of genetic effects in conserved and coding regions and associations with 146 nonsynonymous exonic variants. Associated genes are strongly expressed in the brain, specifically in striatal medium spiny neurons and hippocampal pyramidal neurons. Gene set analyses implicate pathways related to nervous system development and synaptic structure. We confirm previous strong genetic correlations with multiple health-related outcomes, and Mendelian randomization analysis results suggest protective effects of intelligence for Alzheimer's disease and ADHD and bidirectional causation with pleiotropic effects for schizophrenia. These results are a major step forward in understanding the neurobiology of cognitive function as well as genetically related neurological and psychiatric disorders.

39. Caamano-Isorna F, Adkins A, Moure-Rodríguez L, Conley AH, Dick D. (2018) Alcohol Use and Sexual and Physical Assault Victimization Among University Students: Three Years of Follow-Up. J Interpers Violence. doi: 886260518780413.

Abstract: The aim of this study was to determine the incidence of sexual and physical assault among university students and its association with alcohol use. The research is part of a wider cohort study (Spit for ScienceTM) at a large public university in the United States. The follow-up data include the first two cohorts (2011, 2012; n = 5,170). The dependent variables were victim of sexual assault and victim of physical assault. The independent variables were alcohol dependence and abuse according to the Diagnostic and Statistical Manual of Mental Disorders (4th ed.), cannabis use, residence, ethnicity, sexual orientation, and previous experience of sexual assault and/or physical assault. We used multilevel logistic regression for repeated measures. All data were analyzed using generalized linear mixed models. Incidence rates of sexual and physical assault (per 100 students a year) were 15.1 and 27.6 among nonabusers/dependents versus 36.4 and 56.7 among alcohol-dependent females at the first year, and 2.8 and 4.7 versus 7.7 and 23.1 at the third year; while in males, incident rates were 6.0 and 3.1 versus 18.5 and 66.6, and 2.3 and 7.4 versus 18.9 and 15.1, respectively. Our results show that alcohol abuse and dependence constitute risk factors to be victim of sexual assault in males (odds ratio [OR] = 2.21 and OR = 2.73) and alcohol dependence in females (OR = 2.16). Similarly, alcohol abuse and dependence are risk factors to physical assault among both males (OR = 1.52 and OR = 2.03) and females (OR = 1.70 and OR = 2.88). Ethnicity, sexual orientation, and whether the individual had been victimized in the past were associated with sexual assault. Regarding physical assault, cannabis use and past victimization are also risk factors. Our study has shown that assault victimization is strongly related to alcohol abuse and dependence diagnoses in both genders. Ethnicity and sexual orientation are also associated to both assaults. Our results show that incidence rates of both types of assaults were clearly higher in the first 6 months of university, probably explained by the novel and potentially risky environment. 

40. Su, J., Kuo, S. I., Myers, J. M., Guy, M. & Dick, D. M. (2018). Examining interactions between genetic risk for alcohol problems, peer deviance, and interpersonal traumatic    events on trajectory of alcohol use disorder symptoms among African American college   students. Development and Psychopathology.  doi: 10.1017/S0954579418000962

Abstract: Numerous studies have demonstrated that genetic and environmental factors interact to influence alcohol problems. Yet prior research has primarily focused on samples of European descent and little is known about gene-environment interactions in relation to alcohol problems in non-European populations. In this study, we examined whether and how genetic risk for alcohol problems and peer deviance and interpersonal traumatic events independently and interactively influence trajectories of alcohol use disorder symptoms in a sample of African American students across the college years (N = 1,119; Mage = 18.44 years). Data were drawn from the Spit for Science study where participants completed multiple online surveys throughout college and provided a saliva sample for genotyping. Multilevel growth curve analyses indicated that alcohol dependence genome-wide polygenic risk scores did not predict trajectory of alcohol use disorder symptoms, while family history of alcohol problems was associated with alcohol use disorder symptoms at the start of college but not with the rate of change in symptoms over time. Peer deviance and interpersonal traumatic events were associated with more alcohol use disorder symptoms across college years. Neither alcohol dependence genome-wide polygenic risk scores nor family history of alcohol problems moderated the effects of these environmental risk factors on alcohol use disorder symptoms. Our findings indicated that peer deviance and experience of interpersonal traumatic events are salient risk factors that elevate risk for alcohol problems among African American college students. Family history of alcohol problems could be a useful indicator of genetic risk for alcohol problems. Gene identification efforts with much larger samples of African descent are needed to better characterize genetic risk for alcohol use disorders, in order to better understand gene-environment interaction processes in this understudied population.

41. Williams AB, Dzierzewski JM, Griffin SC, Lind MJ, Dick D & Rybarczyk BD. (2019) Insomnia Disorder and Behaviorally Induced insufficient Sleep Syndrome: Prevalence and Relationship to Derpression in College Students. Behav Sleep Med. doi: 10.1080/15402002.2019.1578772.

Abstract: College students are at increased risk for sleep disorders, including insomnia disorder and obtaining less than 6.5 hr of sleep per night by choice, or behaviorally induced insufficient sleep syndrome (BIISS). These disorders can have deleterious daytime consequences, including depression. This study aims to establish the prevalence of insomnia and BIISS disorders and examine associations of insomnia and BIISS with other sleep characteristics and depression. METHODS: A subset of data from Spit for Science, a college risk behaviors and health study (n = 989) was used. Insomnia and BIISS were defined as mutually exclusive disorders, based on diagnostic criteria. RESULTS: A majority (68%) of students were categorized as normal sleepers, followed by insomnia (22%), and BIISS (10%). Sleep duration was comparable between BIISS and insomnia, while daytime sleepiness was significantly higher in BIISS, and sleep latency was longer in insomnia (m = 44 vs. m = 13 min). Insomnia was associated with the highest depression symptoms, followed by BIISS, and normal sleep, controlling for demographics. Insomnia was associated with twice the risk of moderate or higher depression compared to normal sleep (CI: 1.60, 2.70, p < .001). CONCLUSION: These findings highlight the sleep difficulties endemic to college populations. Further, this study provides the first prevalence estimation of BIISS in college students and the first comparison of insomnia and BIISS on sleep characteristics and depressive symptoms. This study underscores the importance of targeted screening and intervention to improve both sleep and depression in this vulnerable population.

42. Cusack SE, Hicks TA, Bourdon J, Sheerin CM, Overstreet CM, Kendler KS, Dick DM & Amstadter AB (2019). Prevalence and predictors of PTSD among a college sample. J Am Coll Health doi: 10.1080/07448481.2018.1462824

Abstract: This study examined the prevalence and correlates of probable posttraumatic stress disorder (PTSD) in freshman entering college and prospective associations of probable PTSD with additional outcomes. Participants: 2,310 students with data collected from Fall 2014 through Spring 2015. Methods: Incoming freshman completed a survey assessing for relevant variables at the beginning of fall semester and during the spring semester. Results: Seventy percent of the sample endorsed experiencing at least one potentially traumatic event (PTE). 34.4% of PTE exposed individuals met criteria for probable PTSD. Female sex, higher depressive and anxiety symptoms, and interpersonal PTE count were positively associated with PTSD symptoms. Higher PTSD symptoms were associated with higher anxiety and depressive symptoms, and new-onset interpersonal PTE. Conclusions: Identification of factors contributing to risk for PTSD is essential to inform prevention and intervention efforts. Intervention efforts should be targeted to students experiencing PTSD symptoms as they enter college.

43. Dillon P, Kendler KS, Dick DM & Svikis D. Gender Differences in Any-Source Caffeine and Energy Drink Use and Associated Adverse Health Behaviors. Journal of caffeine and Adenosine Research 9(1) doi: 10.1089/caff.2018.0008. 

AbstractThe majority of college students report caffeine use with many using caffeine daily. Energy drink (ED) use, in particular, is common among college students, and numerous studies link these heavily caffeinated drinks to a variety of adverse consequences including substance use and risky behaviors. However, little is known about correlations between any-source caffeine use and other substance use and problems. The purpose of this study was to evaluate patterns of caffeine use and examine the relationships between caffeine, in general, and EDs specifically, and adverse health behaviors in college students. Methods:We used data from a longitudinal study of alcohol use and health-related outcomes to assess caffeine, alcohol, nonprescription drug, and tobacco use and symptoms of alcohol dependence in 1958 freshmen from a mid-Atlantic university during Fall 2012. We compared adverse health behaviors between caffeine users and nonusers and ED users and nonusers. Data were evaluated separately in men and women. Results:While women reported significantly more caffeine use than men, men reported more ED use. EDs, regardless of frequency of use, were associated with all adverse health behaviors, but only in female students. Similarly, daily any-source caffeine use was significantly associated with alcohol, nonprescription drug, and tobacco use in female students, but in men, the association was less robust. Conclusions:This research shows that caffeine use is prevalent among college students, and, in female students, is associated with alcohol, nonprescription drug, and tobacco use and alcohol dependence symptoms. Interventions aimed at promoting healthy behaviors may be especially useful in this population.

44. Gnilka PB, Broda MD & The S4S Working Group. Multidimensional Perfectionism, Depression, and Anxiety: Tests of a Social Support Mediation Model. Personality and Individual Differences, 139 (2019) 295-300.

Abstract: This study examined the relationship between multidimensional perfectionism, social support, and two out-comes (depression and anxiety) in a sample of 1785 undergraduate students. Perfectionistic concerns had a negative relationship with social support, and perfectionistic strivings had a positive relationship with social support. The relationships between both dimensions of perfectionism and both outcomes were mediated by social support

45. Smith R, Salvatore J, Aliev F, Neale Z, Barr P, The S4S Working Group & Dick D. Genes, Roommates, and Residence Halls: A Multidimensional Study of the Role of Peer Drinking on College Students’ Alcohol Use. Alcoholism: Clinical and Experimental Research. In press.

Abstract: Peer drinking is one of the most robust predictors of college students’ alcohol use and can moderate students’ genetic risk for alcohol use. Peer effect research generally suffers from two problems: selection into peer groups and relying on perceptions of peer alcohol use than peers’ self-report. The goal of the present study was to overcome those limitations by capitalizing on a genetically-informed sample of randomly assigned college roommates to examine multiple dimensions of peer influence and the interplay between peer effects and genetic predisposition on alcohol use, in the form of polygenic scores. Methods:We used a subsample (n= 755) of participants from a university-wide, longitudinal study at a large, diverse, urban university. Participants reported their own alcohol use during fall and spring and their perceptions of college peers’ alcohol use in spring. We matched individuals into their rooms and residence halls to create a composite score of peer-reported alcohol use for each of those levels. We examined multiple dimensions of peer influence and whether peer influence moderated genetic predisposition to predict college students’ alcohol use using multilevel models to account for clustering at the room and residence hall level. Results:We found that polygenic scores (b= .12), perceptions of peer drinking (b= .37), and roommates’ self-reported drinking (b= .10) predicted alcohol use (all ps < .001), while average alcohol use across residence hall did not (b= -.01, p= .86). We found no evidence for interactions between peer influence and genome-wide polygenic scores for alcohol use. Conclusion:Our findings underscore the importance of genetic predisposition on individual alcohol use and support the potentially causal nature of the association between peer influence on alcohol use.

 

Under Review

  1. Berenz EC, Vukanovic A, Kevorkain S, Gonzales RE, Chowdhurry N, Dutcher CD, Dick DM, Kendler KS, Amstadter AB. Childhood trauma and distress tolerance: A multi-modal study in independent samples. Under review.

  2. Cho SB, Aliev F, Kendler KS, Davies AG, Dick DM, Bettinger JC. The association of C-terminal-binding protein CTBP1 and CTBP2 genes with alcohol problems and externalizing behavior. Under review

  3. Do EK, Cooke M, Dick DM, Kendler KS, Maes H. Prevalence and correlates of tobacco use in Spit for Science. Under review

  4. Overstreet C, Hawn SE, Conley A, Kendler KS, Dick DM, Amstadter AB. Prevalence and predictors of physical assault among a college sample. Under Review

  5. Chartier KG, Tiarsmith EC, O'Shea T, Aliev F, Kendler KS & Dick DM. College Students' use of over-ther-counter medication to dampen the alochol facial flushing response. Under review
  6. Su J, Kuo SI, Derlan, CL, Hagiwara N, Guy MC, Dick DM. Racial Discrimination and Alcohol Problems among African American Young Adults: Examining the Moderating Effects of Parental and Peer Racial Socialization.  Under Review

  7. Zaharakis N, Kliewer W, Su J, The S4S working group, Dick DM. Parents Talk Pot Reactively: Cross-Lagged Panel Models Testing Cannabis Communication and Use. Under Review.

  8. Bountress KE, Hawn SE, Dick DM, The S4S Working Group, & Amstadter AB. Latent Classes of Alcohol Consumption Among Trauma-Exposed College Students: Associations with Demographic

  9. Hawn, S.E., Bountress, K.E., Sheerin, C., Spit for Science Working Group, Dick, D., Amstadter, A.B. (under review). Trauma-related drinking to cope: A novel approach to the self-medication model.
  10. Paltell KC, Smith RL, Kansky J, Cox CM, Amstadter AB, Dick, DM, The Spit for Science Working group, Salvatore JE & Berenz EC Posttraumatic Stress Disorder Symptoms, Relationship Quality, and Risky Alcohol Use among Trauma-Exposed College Students. Under Review
  11. Cusack SE, Bountress KE, Lind, MJ, Hawn SE, The S4S Working Group, Dick DM and Amstadter AB. (under review) Trauma exposure, alcohol consumption, and sleep quality: A latent growth curve model
  12. Hawn, S.E., Aggen, S., Cusack, S.E., Spit for Science Working Group, Dick, D.M., & Amstadter, A.B. (under review). Examination of a novel measure of trauma-related drinking to cope. Psychological Methods.